Principal Scientist

Job title:

Principal Scientist

Company

GlaxoSmithKline

Job description

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.Discover more about our company wide benefits and life at GSK on our webpagePrincipal Scientist, Computational ChemistryWe are seeking a highly motivated Principal Scientist within the Molecular Design team to support research activities across multiple therapeutic areas and drug modalities. The position will involve application of computational chemistry methods and innovative science to drug discovery programs. You will get the opportunity to work in a large computational science department interacting with a range of talented scientists, across the UK and US, with various backgrounds and experience.We are looking for this role to be based at Stevenage, UK.In this role you will…

• Apply cutting edge computational chemistry techniques to drive multiparameter optimisation in drug discovery programs
• Work on inter-disciplinary teams providing computational design of experiments, including data generation to strengthen models
• Develop new capabilities and infrastructure which assist other scientists in their work and maintain GSK’s powerful suite of design tools
• Work closely with colleagues from other disciplines in a matrix environment, communicating complex scientific ideas to partners with a range of backgrounds

Basic Qualifications/Experience:We are looking for professionals with these required skills to achieve our goals:

• PhD, MSc or equivalent in chemistry, pharmacy or a closely related discipline
• Experience in one or more of the following: Virtual screening, structure-based and ligand-based approaches to design small molecules, Machine Learning and QSAR modelling, Free Energy prediction.
• Demonstrated scientific contributions documented with publications and/or presentations

Preferred Qualifications/Experience:If you have the following characteristics, it would be a plus:

• Knowledge of the drug discovery process, for example medicinal chemistry, toxicology, DMPK, and/or screening data analysis
• Experience with commercial modelling tools, eg Schrodinger, CCG, etc
• Experience in python scripting
• Strong knowledge of chemical and protein structure
• Experience with PROTAC or Antibody Drug Conjugate (ADC) design
• Experience with array design or synthetic tractability prediction

Closing Date for Applications – Thursday 1st May 2025Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.GSK R&DAt GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We’re uniting science, technology and talent to get ahead of disease together.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or 0808 234 4391. The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary.Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the and scroll to the Careers Section where you will find answers to multiple questions we receive .Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at

Expected salary

Location

Stevenage, Hertfordshire

Job date

Sat, 19 Apr 2025 03:50:35 GMT

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