Research associate in Germ Cell Cancer Genes 1/2024/EMBO

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Research associate in Germ Cell Cancer Genes 1/2024/EMBO

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Offer Description

• General information about employment conditions:

a. Position -Research assistantb. Type of employment: full-time employment contractc. Workplace: IBM PAS2. The scope of tasks:The aim of meiosis is to generate gametes by recombining the chromosomes and reducing the genome from diploid to haploid. However, in mitosis haploid genome and recombination have catastrophic, oncogenic outcomes. Consequently, the process of somatic cell division requires the accurate and specific silencing of meiotic genes when cells transition to mitosis. Interestingly, failure of this silencing occurs in approximately 30-50% of human cancer patients who re-express the meiotic SC proteins. We find that this re-expression is induced by common chemotherapy treatments causing DNA damage induction. The process of meiotic recombination involves similar mechanisms to DNA double strand break repair (DSBR) and due to this similarity SC re-activation in cancer cells may contribute to genome instability. In this project you will investigate potential mechanisms driving SC re-expression in cancer. You will investigate the biology of SC in meiosis and during re-expression in cancer, the effect this has on cellular physiology and response to chemotherapeutics. This interdisciplinary project will involve a unique breadth of training with complementary approaches. During this interdisciplinary project you will utilise a combination of skills in pathology, cell biology, big data, proteomics, genetic and imaging techniques. A broad range of inter-disciplinary approaches (CRISPR-Cas9 genome editing and DNA pull-downs followed by mass spectroscopy) will help you develop diverse technical expertise. Furthermore, this multi disciplinary post will give you a broad range of skills allowing a wide choice of career options, both within and outside of academia. Our group is committed to supporting the development of early career researchers. Successful candidate will not only join a vibrant department but will also be supported in attending national and international conferences as well as undertaking training to further develop and pursue their own career development. Our laboratory is a collegial, supportive environment that champions talent, diversity and equity.Where to apply E-mail[email protected]RequirementsResearch Field Biological sciences » Biology Education Level Master Degree or equivalentResearch Field Biological sciences » Biology Education Level PhD or equivalentResearch Field Medical sciences » Cancer research Education Level Master Degree or equivalentResearch Field Medical sciences » Cancer research Education Level PhD or equivalentSkills/Qualifications

• Research assistant

a. Education: BSc or MSc/ MRes/ MPhil in biology or a related science in biology or a related scienceb. Professional experience: experience in molecular and cell biology, knowledge of experimental techniques used in cell biology, knowledge of instrumental analysis methods to analyze gene expression and protein biology,c. Professional skills: organisational skills, fluency in spoken and written English, written and spoken polishd. Personal predispositions: responsible, able to work as part of a team, enthusiastic, self-driven, good communicator2. Post-doctoral Research associatea. Education: PhD in biology or a related scienceb. Professional experience: experience in molecular and cell biology, knowledge of experimental techniques used in cell biology, knowledge of instrumental analysis methods to analyze gene expression and protein biology, ability to plan and conduct molecular experiments, ability to independently analyse experimental results.c. Professional skills: the ability to extract information from literature as well as public resources and databases such as deepmap and C-bioportal, ability to use statistical software, ability to present results in public, organisational skills, fluency in spoken and written English, written and spoken polishd. Personal predispositions: creativity in solving research problems, responsible, able to work as part of a team, enthusiastic, self-driven, good communicatorSpecific Requirements-CV including a description of academic achievements, awards, scholarships, participation in conferences and training as well as publications-cover letter-a copy/duplicate of the diploma-the candidate’s consent to us processing your personal data for the recruitment process as required by the Personal Data Protection Act of 29.08.1997 – candidates who do not include this data processing statement will unfortunately not be considered(Journal of Laws No. 133 item 883). Please read the information clause for candidates applying for the position of Assistant (available in the advertisement on the website of the Institute of Medical Biology PAS) and include the following consent in your application documents:I consent to the processing of my data by the Institute of Medical Biology of the Polish Academy of Sciences, based in Łódź, provided in the application documents submitted by me for the purposes necessary for the recruitment process, by Article 6(1)(a) of the Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons about the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (starting now: RODO) and declare that I have been instructed about my rightsNAME .. DATE Languages POLISH Level GoodLanguages ENGLISH Level GoodResearch Field Medical sciences » Cancer research Years of Research Experience 1 – 4Research Field Biological sciences » Biology Years of Research Experience 1 – 4Additional InformationBenefitsAs an EMBO funded laboratory we offer you access to an international collaborative network as well as an opportunity to complete placements within laboratories in Western Europe and US.Selection processDocuments will be accepted until 1st December 2024:– directly at the Reception of the Institute of Medical Biology of the Polish Academy of Sciences, 93-232 Łódź, 106 Lodowa St., daily from Monday to Friday from 9.00 a.m. to 4.00 p.m., with the annotation: “Competition – offer no. 1/2024/EMBO”,or-by post to the address of the Institute with the annotation: “Competition – offer no. 1/2024/EMBO”, or-via email to: and . Please indicate in the title of the e-mail: “Competition – offer no. 1/2024/EMBO”.After the initial verification and evaluation of the documents, selected candidates will be invited for an interview, through which a person offered the above-mentioned position will be chosen.Interviews are scheduled for December 9-10th, 2024.On December 12th 2024, the results of the recruitment process will be announced. The offer of employment will then be forwarded to the Institute’s HR Department for further administrative processing to allow for hiring of the successful candidate.The organisers reserve the right to contact only selected candidates following verification of the submitted documents, we reserve the right to reject all submitted offers if the selection panel considers their qualifications to be inadequate. At the same time, we would like to inform the applicants that the documents we receive will not be returned.Additional commentsAdditional information may be obtained from Dr Urszula McClurg ( ). Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Institute of Medical Biology Polish Academy of Sciences Country Poland City Lodz Postal Code 93-232 Street 106, Lodowa St. GeofieldContact CityLodz WebsiteStreet106, Lodowa St. Postal Code93-232 E-Mail[email protected]STATUS: EXPIREDShare this page

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Embo, Highland

Job date

Sun, 10 Nov 2024 23:25:19 GMT

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